Description
DiffBase is an online database of Toxin A (TcdA) and Toxin B (TcdB) protein sequences derived from currently available C. difficile strains. TcdA and TcdB have been bioinformatically classified into distinct groups (subtypes) based on their sequence similarities. The full bioinformatic analysis pipeline is described here: github.com/doxeylab/diffbase.
Citation
Mansfield, M.J., Tremblay, B.J.M., Zeng, J., Wei, X., Hodgins, H., Worley, J., Bry, L., Dong, M., and Doxey, A.C. (2020). Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B. PLOS Pathogens 16(12): e1009181. https://doi.org/10.1371/journal.ppat.1009181.
Funding
This project was funded by NSERC. 