DiffBase: A bioinformatic classification of C. difficile toxins



DiffBase is an online database of Toxin A (TcdA) and Toxin B (TcdB) protein sequences derived from currently available C. difficile strains. TcdA and TcdB have been bioinformatically classified into distinct groups (subtypes) based on their sequence similarities. The full bioinformatic analysis pipeline is described here: github.com/doxeylab/diffbase.


Mansfield, M.J., Tremblay, B.J.M., Zeng, J., Wei, X., Hodgins, H., Worley, J., Bry, L., Dong, M., and Doxey, A.C. (2020). Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B. PLOS Pathogens 16(12): e1009181. https://doi.org/10.1371/journal.ppat.1009181.


This project was funded by NSERC.